Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:ABC_transporter |
| gptkbp:alternativeName |
gptkb:MDR1
ATP-binding cassette sub-family B member 1 multidrug resistance protein 1 |
| gptkbp:discoveredBy |
gptkb:Victor_Ling
|
| gptkbp:discoveredIn |
1976
|
| gptkbp:encodedBy |
gptkb:ABCB1_gene
|
| gptkbp:Entrez_Gene_ID |
gptkb:ABCB1
|
| gptkbp:foundIn |
humans
other mammals |
| gptkbp:function |
multidrug resistance
drug efflux pump |
| gptkbp:hasPolymorphism |
C1236T
C3435T G2677T/A |
| gptkbp:HGNC_ID |
HGNC:40
|
| gptkbp:inhibitedBy |
gptkb:tariquidar
gptkb:verapamil quinidine cyclosporine A |
| gptkbp:locatedOnChromosome |
chromosome 7q21.12 (human)
|
| gptkbp:location |
gptkb:cell_membrane
gptkb:kidney gptkb:blood-brain_barrier liver intestinal epithelium |
| gptkbp:molecularWeight |
~170 kDa
|
| gptkbp:OMIM |
171050
|
| gptkbp:orthologIn |
mouse Abcb1a
mouse Abcb1b |
| gptkbp:role |
pharmacokinetics
drug distribution chemotherapy resistance drug absorption drug excretion |
| gptkbp:significance |
affects blood-brain barrier permeability
affects oral bioavailability of drugs impacts drug resistance in cancer |
| gptkbp:structure |
each half has six transmembrane domains
two ATP-binding sites two homologous halves |
| gptkbp:substrate |
antibiotics
antiviral drugs anticancer drugs immunosuppressants |
| gptkbp:UniProtID |
P08183
|
| gptkbp:bfsParent |
gptkb:DB06151
gptkb:ATP-binding_cassette_transporter_family gptkb:Multidrug_resistance_protein_1 |
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
P-glycoprotein
|