|
gptkbp:instanceOf
|
gptkb:protein
ABC transporter
|
|
gptkbp:alternativeName
|
gptkb:MDR1
ATP-binding cassette sub-family B member 1
multidrug resistance protein 1
|
|
gptkbp:discoveredBy
|
gptkb:Victor_Ling
|
|
gptkbp:discoveredIn
|
1976
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gptkbp:encodedBy
|
gptkb:ABCB1_gene
|
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gptkbp:Entrez_Gene_ID
|
gptkb:ABCB1
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:function
|
multidrug resistance
drug efflux pump
|
|
gptkbp:hasPolymorphism
|
C1236T
C3435T
G2677T/A
|
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gptkbp:HGNC_ID
|
HGNC:40
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P-glycoprotein
|
|
gptkbp:inhibitedBy
|
gptkb:tariquidar
gptkb:verapamil
quinidine
cyclosporine A
|
|
gptkbp:locatedOnChromosome
|
chromosome 7q21.12 (human)
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:kidney
gptkb:blood-brain_barrier
liver
intestinal epithelium
|
|
gptkbp:molecularWeight
|
~170 kDa
|
|
gptkbp:OMIM
|
171050
|
|
gptkbp:orthologIn
|
mouse Abcb1a
mouse Abcb1b
|
|
gptkbp:role
|
pharmacokinetics
drug distribution
chemotherapy resistance
drug absorption
drug excretion
|
|
gptkbp:significance
|
affects blood-brain barrier permeability
affects oral bioavailability of drugs
impacts drug resistance in cancer
|
|
gptkbp:structure
|
each half has six transmembrane domains
two ATP-binding sites
two homologous halves
|
|
gptkbp:substrate
|
antibiotics
antiviral drugs
anticancer drugs
immunosuppressants
|
|
gptkbp:UniProtID
|
P08183
|
|
gptkbp:bfsParent
|
gptkb:DB06151
gptkb:ABC_transporter_family
gptkb:ABC_transporter
gptkb:MDR1
gptkb:MDR1_gene
gptkb:ATP-binding_cassette_transporter_family
gptkb:Multidrug_resistance_protein_1
gptkb:DB04876
|
|
gptkbp:bfsLayer
|
7
|