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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alias
|
gptkb:E3_ubiquitin-protein_ligase_Mdm2
Double minute 2 protein
HDMX-interacting protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:biologicalProcess
|
protein binding
protein ubiquitination
ubiquitin-protein transferase activity
regulation of transcription, DNA-templated
transcription corepressor activity
negative regulation of apoptotic process
response to DNA damage stimulus
zinc ion binding
negative regulation of cell cycle arrest
|
|
gptkbp:cellularComponent
|
cytosol
nucleoplasm
nuclear body
|
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gptkbp:discoveredBy
|
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
MDM2 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000135679
4193
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
|
|
gptkbp:HGNC_ID
|
6973
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MDM2 protein
|
|
gptkbp:inhibitedBy
|
p53-mediated transcription
|
|
gptkbp:interactsWith
|
gptkb:Ribosomal_proteins
gptkb:p53_protein
ARF protein
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:12q15
|
|
gptkbp:molecularWeight
|
~55 kDa
|
|
gptkbp:OMIM
|
164785
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1Z1M
4HG7
5C5A
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
NP_002383.2
|
|
gptkbp:regulates
|
gptkb:p53_protein
|
|
gptkbp:role
|
gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
colorectal cancer
leukemia
osteosarcoma
liposarcoma
|
|
gptkbp:structure
|
contains RING finger domain
contains acidic domain
contains p53-binding domain
contains zinc finger domain
|
|
gptkbp:target
|
gptkb:RG7112
gptkb:Nutlin-3
AMG 232
Idasanutlin
MI-773
|
|
gptkbp:UniProtID
|
gptkb:Q00987
|
|
gptkbp:bfsParent
|
gptkb:RG7112
gptkb:idasanutlin
gptkb:AATF_protein
|
|
gptkbp:bfsLayer
|
7
|