Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:challenges |
can lead to p53 activation
|
| gptkbp:code |
chromosome 12
|
| gptkbp:discovered_by |
gptkb:Dr._David_Lane
|
| gptkbp:form |
MDM2-S, MDM2-ALT1
|
| gptkbp:function |
regulates the p53 tumor suppressor
|
| https://www.w3.org/2000/01/rdf-schema#label |
MDM2 protein
|
| gptkbp:initiated_by |
gptkb:Nutlin-3
small molecules p53 transcriptional activity |
| gptkbp:interacts_with |
ARF protein
binds to p53 other E3 ligases |
| gptkbp:involved_in |
cell cycle regulation
|
| gptkbp:is_associated_with |
chronic diseases
tumor microenvironment poor prognosis in cancers viral oncogenes |
| gptkbp:is_expressed_at |
high levels in tumors
|
| gptkbp:is_expressed_in |
various tissues
regulated by oncogenes |
| gptkbp:is_found_in |
human cells
|
| gptkbp:is_involved_in |
DNA damage response
cellular homeostasis cellular metabolism cellular response to stress tumor suppression cellular signaling pathways cellular repair mechanisms cellular signaling cascades immune evasion tumorigenic processes |
| gptkbp:is_involved_in_mechanism_of |
chemoresistance
|
| gptkbp:is_known_to |
affect apoptosis pathways
affect gene expression influence cell fate modulate apoptosis modulate immune responses regulate cell survival |
| gptkbp:is_linked_to |
cellular aging
cellular differentiation metastasis tumor progression therapeutic resistance |
| gptkbp:is_linked_to_pathology |
sarcomas
|
| gptkbp:is_part_of |
cellular stress response
tumor suppressor network cancer signaling pathways oncogenic signaling networks |
| gptkbp:is_part_of_complex |
gptkb:MDM2-p53_complex
|
| gptkbp:is_recognized_as |
mouse model
|
| gptkbp:is_regulated_by |
cellular proliferation
cellular apoptosis micro RNAs |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
therapeutic agents
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:overexpression |
leads to tumorigenesis
|
| gptkbp:pathway |
p53 signaling pathway
|
| gptkbp:promoter |
gptkb:MDM2
|
| gptkbp:promotes |
p53 degradation
|
| gptkbp:role |
ubiquitin ligase
|
| gptkbp:targets |
gptkb:p53
|
| gptkbp:type |
E3 ubiquitin-protein ligase
|
| gptkbp:weight |
approximately 90 k Da
|
| gptkbp:bfsParent |
gptkb:MDM2
|
| gptkbp:bfsLayer |
5
|