|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:category
|
antidepressant
psychotropic medication
|
|
gptkbp:contraindication
|
gptkb:tricyclic_antidepressants
gptkb:SSRIs
sympathomimetic drugs
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:drugInteraction
|
gptkb:dextromethorphan
gptkb:meperidine
tyramine-containing foods
|
|
gptkbp:effect
|
increases levels of dopamine
increases levels of norepinephrine
increases levels of serotonin
|
|
gptkbp:example
|
gptkb:isocarboxazid
gptkb:phenelzine
gptkb:tranylcypromine
gptkb:selegiline
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAOI
|
|
gptkbp:mechanismOfAction
|
inhibits monoamine oxidase enzyme
|
|
gptkbp:prescriptionStatus
|
prescription only
|
|
gptkbp:riskFactor
|
gptkb:serotonin_syndrome
|
|
gptkbp:routeOfAdministration
|
oral
transdermal patch
|
|
gptkbp:sideEffect
|
weight gain
insomnia
sexual dysfunction
hypertensive crisis with tyramine
|
|
gptkbp:standsFor
|
Monoamine oxidase inhibitor
|
|
gptkbp:usedFor
|
gptkb:Parkinson's_disease
gptkb:depression
anxiety disorders
|
|
gptkbp:bfsParent
|
gptkb:Bupropion
|
|
gptkbp:bfsLayer
|
7
|