Ligand-Gated Ion Channel family
GPTKB entity
Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:LGIC_family
|
| gptkbp:discoveredBy |
gptkb:Bernard_Katz
|
| gptkbp:example |
gptkb:GABA_A_receptor
gptkb:AMPA_receptor gptkb:NMDA_receptor gptkb:kainate_receptor gptkb:5-HT3_receptor gptkb:glycine_receptor nAChR |
| gptkbp:firstDescribed |
20th century
|
| gptkbp:foundIn |
animals
fungi plants |
| gptkbp:function |
mediate ion flow across cell membranes in response to ligand binding
|
| gptkbp:GO_term |
GO:0015276
|
| https://www.w3.org/2000/01/rdf-schema#label |
Ligand-Gated Ion Channel family
|
| gptkbp:includes |
gptkb:GABA_A_receptor
gptkb:glycine_receptor gptkb:serotonin_5-HT3_receptor nicotinic acetylcholine receptor ionotropic glutamate receptor |
| gptkbp:InterPro |
IPR006201
|
| gptkbp:involvedIn |
central nervous system function
fast synaptic transmission peripheral nervous system function |
| gptkbp:mechanismOfAction |
open in response to binding of a chemical messenger (ligand)
|
| gptkbp:memberOf |
transmembrane receptor superfamily
|
| gptkbp:modulatedBy |
antagonists
allosteric modulators agonists inhibitors potentiators |
| gptkbp:mutationAssociatedWith |
associated with neurological disorders
|
| gptkbp:permeableTo |
chloride ions
calcium ions potassium ions sodium ions |
| gptkbp:proteinFamily |
PF00060
|
| gptkbp:relatedTo |
voltage-gated ion channel family
|
| gptkbp:role |
synaptic transmission
neurotransmission |
| gptkbp:structure |
typically composed of multiple subunits
|
| gptkbp:subunit |
alpha subunit
beta subunit gamma subunit delta subunit |
| gptkbp:target |
pharmacological agents
|
| gptkbp:UniProtKeyword |
KW-0417
|
| gptkbp:bfsParent |
gptkb:LGIC_family
|
| gptkbp:bfsLayer |
7
|