|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:voltage-gated_potassium_channel
gptkb:protein
|
|
gptkbp:activatedBy
|
serotonin
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:HTR3A_gene
HTR3B gene
HTR3C gene
HTR3D gene
HTR3E gene
|
|
gptkbp:enemyOf
|
gptkb:ondansetron
gptkb:dolasetron
gptkb:granisetron
gptkb:palonosetron
gptkb:tropisetron
2-methyl-5-HT
m-chlorophenylbiguanide
|
|
gptkbp:Entrez_Gene_ID
|
3359
|
|
gptkbp:foundIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:function
|
mediates fast excitatory neurotransmission
involved in pain perception
involved in vomiting reflex
|
|
gptkbp:hasClinicalUse
|
irritable bowel syndrome
psychiatric disorders (investigational)
chemotherapy-induced nausea and vomiting
postoperative nausea and vomiting
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
5-HT3 receptor
|
|
gptkbp:locatedOn
|
chromosome 11
|
|
gptkbp:memberOf
|
gptkb:Cys-loop_receptor_family
|
|
gptkbp:OMIM
|
182138
|
|
gptkbp:PDB
|
6HIO
|
|
gptkbp:permeableTo
|
K+
Ca2+
Na+
|
|
gptkbp:structure
|
pentameric
|
|
gptkbp:subunit
|
A subunit
B subunit
C subunit
D subunit
E subunit
|
|
gptkbp:symbol
|
gptkb:HTR3A
gptkb:HTR3B
gptkb:HTR3C
gptkb:HTR3D
gptkb:HTR3E
|
|
gptkbp:target
|
antiemetic drugs
|
|
gptkbp:UniProtID
|
P46098
|
|
gptkbp:bfsParent
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:bfsLayer
|
6
|