|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
AXIL
ODCRCS
PPP1R49
|
|
gptkbp:encodes
|
axin-2 protein
|
|
gptkbp:Entrez_Gene_ID
|
8313
ENSG00000168646
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
2000
|
|
gptkbp:foundIn
|
human genome
|
|
gptkbp:fullName
|
axis inhibition protein 2
|
|
gptkbp:function
|
negative regulator of Wnt signaling pathway
|
|
gptkbp:gene
|
gptkb:AXIN2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:902
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AXIN2
|
|
gptkbp:interactsWith
|
gptkb:Dishevelled_proteins
gptkb:GSK3B
gptkb:APC
gptkb:CK1
gptkb:beta-catenin
|
|
gptkbp:involvedIn
|
gptkb:beta-catenin_destruction_complex
|
|
gptkbp:length
|
843 amino acids
|
|
gptkbp:locatedOnChromosome
|
17
|
|
gptkbp:location
|
17q24.1
|
|
gptkbp:molecularWeight
|
~92 kDa
|
|
gptkbp:mutationAssociatedWith
|
colorectal neoplasia
familial tooth agenesis
|
|
gptkbp:OMIM
|
604025
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Axin2
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
cell cycle regulation
|
|
gptkbp:product
|
axin-2
|
|
gptkbp:proteinFamily
|
axin family
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
|
|
gptkbp:relatedTo
|
colorectal cancer
developmental disorders
tooth agenesis
cancer predisposition
craniosynostosis
|
|
gptkbp:UniProtID
|
Q9Y2T1
|
|
gptkbp:bfsParent
|
gptkb:Axin
gptkb:TCF/LEF
gptkb:TCF/LEF_transcription_factors
gptkb:LEF1
gptkb:AXIN
|
|
gptkbp:bfsLayer
|
7
|