ITCHY E3 ubiquitin protein ligase

URI: https://gptkb.org/entity/ITCHY_E3_ubiquitin_protein_ligase
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:Itch
Atrophin-1-interacting protein 4
gptkbp:associatedWith autoimmune disease
gptkbp:biologicalProcess signal transduction
regulation of apoptosis
regulation of cell proliferation
immune system process
protein catabolic process
gptkbp:domain gptkb:WW_domain
gptkb:HECT_domain
gptkbp:Entrez_Gene_ID GC20P034282
gptkbp:enzymeCommissionNumber EC 2.3.2.27
gptkbp:expressedIn gptkb:testis
gptkb:thymus
brain
spleen
lymphoid tissue
gptkbp:function protein ubiquitination
E3 ubiquitin-protein ligase activity
gptkbp:gene gptkb:ITCH
https://www.w3.org/2000/01/rdf-schema#label ITCHY E3 ubiquitin protein ligase
gptkbp:interactsWith gptkb:JUN
gptkb:NEDD4
gptkb:WWP1
gptkbp:locatedOnChromosome 20q11.22
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight ~113 kDa
gptkbp:OMIM 606245
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse Itch (mouse protein)
gptkbp:phosphorylates Serine 161
Serine 257
gptkbp:postTranslationalModification phosphorylation
sumoylation
ubiquitination
gptkbp:proteinFamily HECT E3 ligase family
gptkbp:regulates gptkb:Notch_signaling_pathway
immune response
T cell activation
gptkbp:substrate gptkb:p63
gptkb:p73
gptkb:c-FLIP
gptkb:LATS1
gptkb:JUN
gptkb:CXCR4
Notch intracellular domain
gptkbp:UniProtID Q96J02
gptkbp:bfsParent gptkb:WW_domain
gptkbp:bfsLayer 7