ITCHY E3 ubiquitin protein ligase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:Itch Atrophin-1-interacting protein 4
gptkbp:associatedWith	gptkb:autoimmune_disease
gptkbp:biologicalProcess	signal transduction regulation of apoptosis regulation of cell proliferation immune system process protein catabolic process
gptkbp:domain	gptkb:WW_domain gptkb:HECT_domain
gptkbp:Entrez_Gene_ID	GC20P034282
gptkbp:enzymeCommissionNumber	EC 2.3.2.27
gptkbp:expressedIn	gptkb:testis gptkb:thymus gptkb:lymphoid_tissue brain spleen
gptkbp:function	protein ubiquitination E3 ubiquitin-protein ligase activity
gptkbp:gene	gptkb:ITCH
gptkbp:interactsWith	gptkb:JUN gptkb:NEDD4 gptkb:WWP1
gptkbp:locatedOnChromosome	20q11.22
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:molecularWeight	~113 kDa
gptkbp:OMIM	606245
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	Itch (mouse protein)
gptkbp:phosphorylates	Serine 161 Serine 257
gptkbp:postTranslationalModification	phosphorylation sumoylation ubiquitination
gptkbp:proteinFamily	HECT E3 ligase family
gptkbp:regulates	gptkb:Notch_signaling_pathway gptkb:immune_response T cell activation
gptkbp:substrate	gptkb:p63 gptkb:p73 gptkb:c-FLIP gptkb:LATS1 gptkb:JUN gptkb:CXCR4 Notch intracellular domain
gptkbp:UniProtID	Q96J02
gptkbp:bfsParent	gptkb:WW_domain
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	ITCHY E3 ubiquitin protein ligase