|
gptkbp:instanceOf
|
gptkb:protein
guanine nucleotide exchange factor
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alias
|
gptkb:K-Ras
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
K-Ras2
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:KRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signal transduction
regulation of cell differentiation
regulation of cell proliferation
regulation of cell survival
|
|
gptkbp:HGNC_ID
|
6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRas protein
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
RAF/MEK/ERK cascade
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 12p12.1
|
|
gptkbp:memberOf
|
gptkb:RAS_family
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:endometrial_cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:orthologIn
|
gptkb:entomologist
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:4OBE
6GJ8
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:structure
|
contains G domain
contains switch I region
contains switch II region
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:target
|
gptkb:adagrasib
gptkb:sotorasib
gptkb:AMG_510
gptkb:MRTX849
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:HRas_protein
gptkb:Kras_(mouse)
|
|
gptkbp:bfsLayer
|
7
|