Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
metabolite alpha-keto acid |
| gptkbp:alsoKnownAs |
gptkb:alpha-ketoglutarate
2-oxopentanedioic acid 2-ketoglutaric acid |
| gptkbp:CASNumber |
328-50-7
|
| gptkbp:chemicalFormula |
C5H6O5
|
| gptkbp:foundIn |
mitochondria
|
| gptkbp:hasRole |
gptkb:coenzyme
metabolite enzyme substrate |
| https://www.w3.org/2000/01/rdf-schema#label |
2-oxoglutarate
|
| gptkbp:involves |
energy production
collagen synthesis cancer metabolism epigenetic regulation redox balance amino acid metabolism cellular respiration nitrogen metabolism tricarboxylic acid cycle TCA cycle metabolic regulation anaplerotic reactions RNA modification DNA demethylation ammonia assimilation histone demethylation oxidative decarboxylation carbon metabolism transamination reactions hypoxia response dioxygenase reactions glutaminolysis hydroxylation reactions lysyl hydroxylase activity prolyl hydroxylase activity |
| gptkbp:isConjugateBaseOf |
2-oxoglutarate(2-)
|
| gptkbp:IUPACName |
2-oxopentanedioic acid
|
| gptkbp:mass |
146.11 g/mol
|
| gptkbp:partOf |
citric acid cycle
|
| gptkbp:predecessor |
gptkb:glutamine
glutamate arginine proline |
| gptkbp:producedBy |
gptkb:isocitrate_dehydrogenase
|
| gptkbp:substrate |
gptkb:alpha-ketoglutarate_dehydrogenase
|
| gptkbp:bfsParent |
gptkb:alpha-ketoglutarate
|
| gptkbp:bfsLayer |
6
|