|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
inflammation
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:contains
|
gptkb:c-Jun
gptkb:JunD
gptkb:JunB
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:domain
|
basic leucine zipper domain
|
|
gptkbp:encodedBy
|
gptkb:JUN_gene
JUND gene
JUNB gene
|
|
gptkbp:expressedIn
|
eukaryotic cells
|
|
gptkbp:form
|
heterodimers
homodimers
|
|
gptkbp:formsHeterodimerWith
|
ATF proteins
Fos proteins
Maf proteins
|
|
gptkbp:function
|
transcription regulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Jun proteins
|
|
gptkbp:involvedIn
|
apoptosis
cell proliferation
differentiation
oncogenesis
|
|
gptkbp:memberOf
|
AP-1 transcription factor complex
|
|
gptkbp:modulatedBy
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:molecularWeight
|
~34 kDa (JunD)
~35 kDa (JunB)
~39 kDa (c-Jun)
|
|
gptkbp:namedAfter
|
jun oncogene
|
|
gptkbp:orthologIn
|
gptkb:human
gptkb:mouse
right
Drosophila melanogaster (Jra protein)
|
|
gptkbp:phosphorylates
|
gptkb:JNK_(c-Jun_N-terminal_kinase)
|
|
gptkbp:regulates
|
gene expression
immune response
cell cycle
stress response
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
gptkb:JNK_signaling_pathway
gptkb:MAPK_signaling_pathway
cytokines
growth factors
|
|
gptkbp:bfsParent
|
gptkb:Fos
gptkb:FosB
gptkb:Fra-1
|
|
gptkbp:bfsLayer
|
8
|