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gptkbp:instanceOf
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gptkb:protein
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gptkbp:abbreviation
|
gptkb:JAK
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gptkbp:activatedBy
|
cytokine binding
|
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gptkbp:associatedWith
|
cytokine receptors
|
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gptkbp:discoveredBy
|
Darnell, Stark, and colleagues
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gptkbp:EC_number
|
2.7.10.2
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gptkbp:enzymeClassification
|
transferase
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gptkbp:foundIn
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gptkb:cell_membrane
gptkb:cytoplasm
|
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gptkbp:function
|
signal transduction
tyrosine kinase activity
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|
https://www.w3.org/2000/01/rdf-schema#label
|
Janus kinase
|
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gptkbp:inhibitedBy
|
gptkb:ruxolitinib
gptkb:tofacitinib
gptkb:baricitinib
|
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gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
|
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gptkbp:locatedOnChromosome
|
chromosome 1 (JAK1)
chromosome 19 (JAK3)
chromosome 21 (TYK2)
chromosome 9 (JAK2)
|
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gptkbp:medicalUse
|
treatment of psoriasis
treatment of rheumatoid arthritis
treatment of myelofibrosis
|
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gptkbp:member
|
gptkb:JAK2
gptkb:JAK1
gptkb:TYK2
gptkb:JAK3
|
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gptkbp:mutationAssociatedWith
|
gptkb:polycythemia_vera
essential thrombocythemia
primary myelofibrosis
|
|
gptkbp:namedAfter
|
Roman god Janus
|
|
gptkbp:orthologIn
|
C. elegans JAK/STAT pathway proteins
Drosophila Hopscotch protein
|
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gptkbp:phosphorylates
|
gptkb:STAT_proteins
|
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gptkbp:relatedTo
|
gptkb:cancer
autoimmune diseases
|
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gptkbp:structure
|
contains kinase domain
contains pseudokinase domain
contains FERM domain
contains SH2 domain
|
|
gptkbp:target
|
JAK inhibitors
|
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gptkbp:bfsParent
|
gptkb:JAK
|
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gptkbp:bfsLayer
|
7
|