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Insulin-like growth factor I
URI:
https://gptkb.org/entity/Insulin-like_growth_factor_I
GPTKB entity
Statements (54)
Predicate
Object
gptkbp:instanceOf
gptkb:protein
hormone
gptkbp:abbreviation
gptkb:IGF-1
gptkbp:alternativeName
somatomedin C
gptkbp:amino_acids
70
gptkbp:associatedWith
gptkb:Laron_syndrome
acromegaly
growth hormone deficiency
gptkbp:binds
gptkb:IGF-1_receptor
gptkbp:clinical_use
diagnosis of growth disorders
monitoring growth hormone therapy
gptkbp:discoveredBy
1957
gptkbp:expressedIn
gptkb:thyroid
gptkb:cancer
gptkb:bone
gptkb:skin
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:testis
brain
heart
liver
collagen
spleen
adipose tissue
pancreas
stomach
intestine
gptkbp:foundIn
humans
other mammals
gptkbp:function
regulates cell growth and development
stimulates systemic body growth
inhibits cell death (apoptosis)
gptkbp:gene
gptkb:IGF1
gptkbp:halfLife
12–15 hours
gptkbp:HGNC_ID
5464
https://www.w3.org/2000/01/rdf-schema#label
Insulin-like growth factor I
gptkbp:locatedOnChromosome
chromosome 12q23.2
gptkbp:MeSH_ID
D007333
gptkbp:molecularWeight
7.6 kDa
gptkbp:OMIM
147440
gptkbp:producedBy
liver
gptkbp:RefSeq
gptkb:NP_000609.1
gptkbp:regulates
insulin-like growth factor binding proteins
gptkbp:relatedTo
gptkb:insulin
gptkb:Insulin-like_growth_factor_II
gptkbp:stimulated_by
recombinant human growth hormone
gptkbp:structure
single-chain polypeptide
gptkbp:UniProtID
P05019
gptkbp:bfsParent
gptkb:P08069
gptkb:Insulin-like_growth_factor_II
gptkbp:bfsLayer
8