Insulin-like growth factor I

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:protein
hormone
gptkbp:abbreviation gptkb:IGF-1
gptkbp:alternativeName somatomedin C
gptkbp:amino_acids 70
gptkbp:associatedWith gptkb:Laron_syndrome
acromegaly
growth hormone deficiency
gptkbp:binds gptkb:IGF-1_receptor
gptkbp:clinical_use diagnosis of growth disorders
monitoring growth hormone therapy
gptkbp:discoveredBy 1957
gptkbp:expressedIn gptkb:thyroid
gptkb:cancer
gptkb:bone
gptkb:skin
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:testis
brain
heart
liver
collagen
spleen
adipose tissue
pancreas
stomach
intestine
gptkbp:foundIn humans
other mammals
gptkbp:function regulates cell growth and development
stimulates systemic body growth
inhibits cell death (apoptosis)
gptkbp:gene gptkb:IGF1
gptkbp:halfLife 12–15 hours
gptkbp:HGNC_ID 5464
https://www.w3.org/2000/01/rdf-schema#label Insulin-like growth factor I
gptkbp:locatedOnChromosome chromosome 12q23.2
gptkbp:MeSH_ID D007333
gptkbp:molecularWeight 7.6 kDa
gptkbp:OMIM 147440
gptkbp:producedBy liver
gptkbp:RefSeq gptkb:NP_000609.1
gptkbp:regulates insulin-like growth factor binding proteins
gptkbp:relatedTo gptkb:insulin
gptkb:Insulin-like_growth_factor_II
gptkbp:stimulated_by recombinant human growth hormone
gptkbp:structure single-chain polypeptide
gptkbp:UniProtID P05019
gptkbp:bfsParent gptkb:P08069
gptkb:Insulin-like_growth_factor_II
gptkbp:bfsLayer 8