Insulin-like growth factor I

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:hormone
gptkbp:abbreviation	gptkb:IGF-1
gptkbp:alternativeName	somatomedin C
gptkbp:amino_acids	70
gptkbp:associatedWith	gptkb:Laron_syndrome acromegaly growth hormone deficiency
gptkbp:binds	gptkb:IGF-1_receptor
gptkbp:clinical_use	diagnosis of growth disorders monitoring growth hormone therapy
gptkbp:discoveredBy	1957
gptkbp:expressedIn	gptkb:thyroid gptkb:adipose_tissue gptkb:cancer gptkb:bone gptkb:skin gptkb:collagen gptkb:skeletal_muscle gptkb:kidney gptkb:placenta gptkb:prostate gptkb:testis brain heart liver spleen pancreas stomach intestine
gptkbp:foundIn	humans other mammals
gptkbp:function	regulates cell growth and development stimulates systemic body growth inhibits cell death (apoptosis)
gptkbp:gene	gptkb:IGF1
gptkbp:halfLife	12–15 hours
gptkbp:HGNC_ID	5464
gptkbp:locatedOnChromosome	chromosome 12q23.2
gptkbp:MeSH_ID	D007333
gptkbp:molecularWeight	7.6 kDa
gptkbp:OMIM	147440
gptkbp:producedBy	liver
gptkbp:RefSeq	gptkb:NP_000609.1
gptkbp:regulates	insulin-like growth factor binding proteins
gptkbp:relatedTo	gptkb:insulin gptkb:Insulin-like_growth_factor_II
gptkbp:stimulated_by	gptkb:recombinant_human_growth_hormone
gptkbp:structure	single-chain polypeptide
gptkbp:UniProtID	P05019
gptkbp:bfsParent	gptkb:P08069 gptkb:Insulin-like_growth_factor_II
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	Insulin-like growth factor I