Insulin-like growth factor II

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein growth factor
gptkbp:alternativeSplicing	multiple transcript variants
gptkbp:associatedWith	gptkb:Wilms_tumor gptkb:Beckwith-Wiedemann_syndrome gptkb:Silver-Russell_syndrome
gptkbp:binds	gptkb:IGF-binding_proteins
gptkbp:clinical_use	biomarker for certain cancers
gptkbp:discoveredBy	1960s
gptkbp:downregulation_associated_with	growth retardation
gptkbp:Entrez_Gene_ID	3481
gptkbp:expressed_from	paternal allele
gptkbp:foundIn	humans mammals
gptkbp:function	cell differentiation cell proliferation fetal development regulation of growth and development
gptkbp:gene	gptkb:IGF2
gptkbp:half-life_in_plasma	10-20 minutes
gptkbp:HGNC_ID	HGNC:5466
gptkbp:homology	shares sequence similarity with proinsulin
https://www.w3.org/2000/01/rdf-schema#label	Insulin-like growth factor II
gptkbp:imprint	maternally imprinted
gptkbp:length	180
gptkbp:locatedOnChromosome	gptkb:chromosome_11p15.5
gptkbp:molecularWeight	7.5 kDa
gptkbp:OMIM	147470
gptkbp:orthologIn	gptkb:mouse right other vertebrates
gptkbp:overexpressedIn	tumorigenesis
gptkbp:postTranslationalModification	glycosylation proteolytic processing
gptkbp:producedBy	gptkb:placenta liver other tissues
gptkbp:recipient	gptkb:IGF1_receptor gptkb:IGF2_receptor gptkb:insulin_receptor
gptkbp:regulates	apoptosis metabolism cell growth
gptkbp:relatedTo	gptkb:insulin gptkb:Insulin-like_growth_factor_I
gptkbp:structure	single-chain polypeptide
gptkbp:UniProtID	P01344
gptkbp:bfsParent	gptkb:P08014
gptkbp:bfsLayer	7