ILK (integrin-linked kinase)

URI: https://gptkb.org/entity/ILK_(integrin-linked_kinase)
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName ILK1
Integrin-linked protein kinase
p59ILK
gptkbp:associatedWith gptkb:cancer
gptkb:cardiomyopathy
gptkbp:biologicalProcess cell proliferation
signal transduction
ATP binding
apoptosis regulation
protein kinase activity
regulation of cell shape
cell-matrix adhesion
gptkbp:discoveredBy 1996
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function cell survival
signal transduction
cell migration
cell adhesion
regulation of cytoskeleton
gptkbp:gene ILK
ILK gene
gptkbp:inhibitedBy Cpd22
QLT0267
gptkbp:interactsWith gptkb:AKT1
gptkb:integrins
gptkb:talin
gptkb:Paxillin
PINCH
alpha-parvin
beta-parvin
parvin
gptkbp:locatedIn gptkb:cytoplasm
focal adhesions
gptkbp:locatedOnChromosome 11p15.4
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:part_of_complex ILK-PINCH-parvin complex
gptkbp:phosphorylates gptkb:AKT1
gptkb:GSK3B
gptkbp:regulates cell cycle
actin cytoskeleton
cell motility
integrin signaling
cell survival pathways
gptkbp:structure contains kinase domain
contains ankyrin repeats
gptkbp:UniProtID Q13418
gptkbp:bfsParent gptkb:FERMT2
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label ILK (integrin-linked kinase)