Heat shock protein HSP 90-beta

URI: https://gptkb.org/entity/Heat_shock_protein_HSP_90-beta
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:HSP90B
gptkb:HSP90AB1
gptkbp:cochaperone gptkb:HOP
gptkb:AHA1
gptkb:CDC37
p23
gptkbp:cofactor gptkb:ATP
gptkbp:conservedIn C-terminal domain
N-terminal domain
HSP90 domain
gptkbp:encodedBy HSP90AB1 gene
gptkbp:Entrez_Gene_ID 3326
gptkbp:expressedIn most tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function protein folding
molecular chaperone
prevention of protein aggregation
stabilization of proteins
https://www.w3.org/2000/01/rdf-schema#label Heat shock protein HSP 90-beta
gptkbp:inhibitedBy gptkb:17-AAG
gptkb:geldanamycin
gptkb:radicicol
gptkbp:interactsWith gptkb:steroid_hormone_receptors
gptkb:kinases
transcription factors
gptkbp:locatedOnChromosome gptkb:chromosome_6p21
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:memberOf gptkb:heat_shock_protein_90_family
gptkbp:molecularWeight approximately 83 kDa
gptkbp:OMIM 140572
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:requires cell survival
protein homeostasis
gptkbp:sequence 724 amino acids
gptkbp:significance target for cancer therapy
implicated in cancer
gptkbp:structure homodimer
contains ATPase domain
gptkbp:subunit HSP90 chaperone complex
gptkbp:UniProtID gptkb:P08238
gptkbp:upregulatedBy heat shock
cellular stress
gptkbp:bfsParent gptkb:HSP90AB1
gptkbp:bfsLayer 8