|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
HSF
HSTF1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
stress response
|
|
gptkbp:biologicalProcess
|
protein folding
DNA binding
transcription factor activity
cellular response to stress
response to heat
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
Richard Morimoto
|
|
gptkbp:encodes
|
heat shock factor protein 1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000185122
3297
|
|
gptkbp:firstDescribed
|
1990
|
|
gptkbp:fullName
|
gptkb:heat_shock_transcription_factor_1
|
|
gptkbp:function
|
regulation of heat shock response
transcriptional activation of heat shock proteins
|
|
gptkbp:HGNC_ID
|
gptkb:HSF1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSF1 gene
|
|
gptkbp:interactsWith
|
gptkb:CBP/p300
gptkb:HSP70
gptkb:HSP90
|
|
gptkbp:length
|
529 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24.3
8
|
|
gptkbp:OMIM
|
140580
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Hsf1
|
|
gptkbp:phosphorylates
|
regulates activity
|
|
gptkbp:proteinFamily
|
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:regulates
|
gptkb:HSP27
gptkb:HSP70
gptkb:HSP90
activated by heat shock
HSF family
inhibited by HSP90 binding
|
|
gptkbp:significance
|
overexpressed in some cancers
potential therapeutic target
|
|
gptkbp:UniProtID
|
gptkb:Q00613
|
|
gptkbp:bfsParent
|
gptkb:heat_shock_factor_1_(HSF1)
|
|
gptkbp:bfsLayer
|
8
|