|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
trimerization upon heat shock
|
|
gptkbp:alias
|
HSF
Heat Shock Factor 1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
transcription regulation
DNA binding
cellular response to heat
protein dimerization activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
gptkb:Susan_Lindquist
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodedBy
|
gptkb:HSF1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000185122
3297
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:fullName
|
Heat Shock Factor Protein 1
|
|
gptkbp:function
|
transcription factor
regulation of heat shock response
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO
|
GO:0003700
GO:0006355
GO:0043555
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HSF1
|
|
gptkbp:interactsWith
|
gptkb:HSF2
gptkb:HSP70
gptkb:HSP90
|
|
gptkbp:length
|
529 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24.3
|
|
gptkbp:MIM
|
140580
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:5D5U
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
|
|
gptkbp:regulates
|
negatively regulated by HSP90
expression of heat shock proteins
activated by stress
|
|
gptkbp:significance
|
potential target for cancer therapy
|
|
gptkbp:structure
|
contains DNA-binding domain
contains oligomerization domain
|
|
gptkbp:UniProtID
|
gptkb:Q00613
|
|
gptkbp:bfsParent
|
gptkb:heat_shock_factor_1_(HSF1)
|
|
gptkbp:bfsLayer
|
8
|