heat shock factor 1 (HSF1)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein transcription factor
gptkbp:activation_mechanism	phosphorylation trimerization
gptkbp:alternativeName	gptkb:HSF1 gptkb:heat_shock_transcription_factor_1
gptkbp:binds	gptkb:heat_shock_elements_(HSEs)
gptkbp:discoveredBy	1990
gptkbp:encodedBy	gptkb:HSF1_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000185122 3297
gptkbp:function	activation of heat shock protein genes regulation of heat shock response
https://www.w3.org/2000/01/rdf-schema#label	heat shock factor 1 (HSF1)
gptkbp:interactsWith	gptkb:CBP/p300 gptkb:HSF2 gptkb:HSP90
gptkbp:involves	neurodegenerative diseases cancer progression cellular stress response protein homeostasis
gptkbp:locatedOnChromosome	gptkb:8q24.3
gptkbp:location	gptkb:nucleus
gptkbp:molecularWeight	~57 kDa
gptkbp:OMIM	140580
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	gptkb:Drosophila_melanogaster_Hsf gptkb:Mus_musculus_Hsf1
gptkbp:PDB	gptkb:5D5U
gptkbp:phosphorylates	Ser303 Ser307 Ser326
gptkbp:RefSeq	gptkb:NM_005526
gptkbp:regulates	gptkb:HSP27 gptkb:HSP70 gptkb:HSP90 activated by oxidative stress activated by heat shock activated by proteotoxic stress negatively regulated by HSP90
gptkbp:significance	potential target in cancer therapy implicated in neurodegenerative disease
gptkbp:species_distribution	eukaryotes
gptkbp:structure	contains regulatory domain contains DNA-binding domain contains oligomerization domain
gptkbp:UniProtID	gptkb:Q00613
gptkbp:bfsParent	gptkb:HSP70 gptkb:Hsp70 gptkb:heat_shock_protein_70_family
gptkbp:bfsLayer	7