heat shock transcription factor 1

URI: https://gptkb.org/entity/heat_shock_transcription_factor_1
GPTKB entity
Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:alternativeName gptkb:HSF1
heat shock factor protein 1
gptkbp:associatedWith gptkb:cancer
neurodegenerative diseases
gptkbp:biologicalProcess protein folding
DNA binding
transcriptional activator activity
response to stress
cellular response to heat
gptkbp:discoveredBy 1990
gptkbp:Entrez_Gene_ID gptkb:ENSG00000185122
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function activation of heat shock protein genes
regulation of heat shock response
gptkbp:gene gptkb:HSF1
gptkbp:GO_term GO:0003700
GO:0006355
GO:0043554
https://www.w3.org/2000/01/rdf-schema#label heat shock transcription factor 1
gptkbp:interactsWith gptkb:CBP/p300
gptkb:HSF2
gptkb:HSP90
gptkbp:length 529
gptkbp:locatedOnChromosome gptkb:8q24.3
gptkbp:molecularWeight 57 kDa
gptkbp:OMIM 140580
gptkbp:orthologInMouse Hsf1
gptkbp:PDB gptkb:5D5U
gptkbp:phosphorylates Serine 326
gptkbp:proteinFamily HSF family
gptkbp:RefSeq gptkb:NM_005526
gptkbp:regulates gptkb:HSP27
gptkb:HSP70
gptkb:HSP90
regulated by phosphorylation
activated by heat shock
heat shock response
inhibited by sumoylation
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID gptkb:Q00613
gptkbp:bfsParent gptkb:heat_shock_factor_1_(HSF1)
gptkbp:bfsLayer 8