hypoxia-inducible factors (HIFs)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:transcription_factor gptkb:protein
gptkbp:activatedBy	gptkb:hypoxia
gptkbp:associatedWith	cancer progression inflammation ischemic diseases
gptkbp:binds	gptkb:hypoxia_response_elements_(HREs)
gptkbp:component	gptkb:HIF-1α gptkb:HIF-1β gptkb:HIF-2α gptkb:HIF-3α
gptkbp:degradedBy	gptkb:proteasome gptkb:von_Hippel-Lindau_protein_(VHL)
gptkbp:discoveredBy	gptkb:Gregg_L._Semenza
gptkbp:function	regulation of gene expression in response to low oxygen
gptkbp:gene	gptkb:ARNT gptkb:EPAS1 gptkb:HIF1A
gptkbp:locale	cell nucleus
gptkbp:NobelPrizeYear	gptkb:2019_Nobel_Prize_in_Physiology_or_Medicine
gptkbp:regulates	gptkb:erythropoietin_gene gptkb:glucose_transporter_1_(GLUT1) gptkb:vascular_endothelial_growth_factor_(VEGF) ubiquitination hydroxylation genes involved in angiogenesis genes involved in cell survival genes involved in metabolism oxygen-dependent degradation
gptkbp:bfsParent	gptkb:VHL
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	hypoxia-inducible factors (HIFs)