Hypoxia-inducible factor pathway
GPTKB entity
Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:biological_pathway
|
| gptkbp:activatedBy |
low oxygen levels
|
| gptkbp:associatedWith |
gptkb:cancer
gptkb:anemia ischemia |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:involves |
gptkb:HIF-1α
gptkb:von_Hippel-Lindau_protein_(VHL) gptkb:HIF-2α gptkb:HIF-3α ARNT (HIF-1β) Hypoxia-inducible factor (HIF) prolyl hydroxylase domain proteins (PHDs) |
| gptkbp:regulates |
cell proliferation
angiogenesis glycolysis iron metabolism VEGF expression cell survival under hypoxia glucose transporter expression cellular response to hypoxia cellular oxygen homeostasis erythropoietin production metabolic adaptation to hypoxia |
| gptkbp:target |
therapeutic drugs
|
| gptkbp:bfsParent |
gptkb:ARNT
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
Hypoxia-inducible factor pathway
|