Hypoxia-inducible factor pathway

GPTKB entity

Statements (28)
Predicate Object
gptkbp:instanceOf biological pathway
gptkbp:activatedBy low oxygen levels
gptkbp:associatedWith gptkb:cancer
gptkb:anemia
ischemia
gptkbp:discoveredIn 1990s
https://www.w3.org/2000/01/rdf-schema#label Hypoxia-inducible factor pathway
gptkbp:involves gptkb:HIF-1α
gptkb:von_Hippel-Lindau_protein_(VHL)
gptkb:HIF-2α
gptkb:HIF-3α
ARNT (HIF-1β)
Hypoxia-inducible factor (HIF)
prolyl hydroxylase domain proteins (PHDs)
gptkbp:regulates cell proliferation
angiogenesis
glycolysis
iron metabolism
VEGF expression
cell survival under hypoxia
glucose transporter expression
cellular response to hypoxia
cellular oxygen homeostasis
erythropoietin production
metabolic adaptation to hypoxia
gptkbp:target therapeutic drugs
gptkbp:bfsParent gptkb:ARNT
gptkbp:bfsLayer 7