|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:GLM2
gptkb:BZS
gptkb:DEC
gptkb:MHAM
gptkb:MMAC1
gptkb:PTEN1
gptkb:TEP1
|
|
gptkbp:approvalYear
|
1997
|
|
gptkbp:approvedBy
|
gptkb:phosphatase_and_tensin_homolog
|
|
gptkbp:approvedSymbol
|
gptkb:PTEN
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Bannayan-Riley-Ruvalcaba_syndrome
gptkb:Cowden_syndrome
gptkb:Lhermitte-Duclos_disease
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171862
5728
|
|
gptkbp:essentialGene
|
yes
|
|
gptkbp:fullName
|
gptkb:phosphatase_and_tensin_homolog
|
|
gptkbp:function
|
gptkb:protein
tumor suppressor
lipid phosphatase
|
|
gptkbp:gene
|
gptkb:PTEN
|
|
gptkbp:geneStructure
|
9 exons
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPseudogene
|
yes
|
|
gptkbp:hasTranscriptVariant
|
NM_000314.8
NM_001304717.6
NM_001304718.4
NM_001304719.4
|
|
gptkbp:HGNC_ID
|
10988
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:10988
|
|
gptkbp:isImprinted
|
false
|
|
gptkbp:isTumorSuppressor
|
true
|
|
gptkbp:length
|
403 amino acids
|
|
gptkbp:locatedOnChromosome
|
10
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locusType
|
gptkb:10q23.31
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:mutationAssociatedWith
|
loss of function leads to tumorigenesis
|
|
gptkbp:OMIM
|
601728
|
|
gptkbp:orthologIn
|
gptkb:mouse_Pten
gptkb:zebrafish_ptena
gptkb:zebrafish_ptenb
|
|
gptkbp:proteinFamily
|
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:RefSeq
|
gptkb:NM_000314
|
|
gptkbp:regulates
|
gptkb:PI3K/AKT_pathway
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:P60484
|
|
gptkbp:bfsParent
|
gptkb:O43175
gptkb:SLC33A1
|
|
gptkbp:bfsLayer
|
7
|