|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:phosphatase_and_tensin_homolog_deleted_on_chromosome_10
gptkb:BZS
gptkb:MHAM
gptkb:MMAC1
gptkb:PTEN1
gptkb:TEP1
gptkb:mutated_in_multiple_advanced_cancers_1
|
|
gptkbp:approvalYear
|
1997
|
|
gptkbp:approvedBy
|
gptkb:phosphatase_and_tensin_homolog
|
|
gptkbp:approvedSymbol
|
gptkb:PTEN
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Bannayan-Riley-Ruvalcaba_syndrome
gptkb:Cowden_syndrome
gptkb:Lhermitte-Duclos_disease
gptkb:endometrial_cancer
gptkb:glioblastoma
prostate cancer
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171862
5728
|
|
gptkbp:enzyme
|
true
|
|
gptkbp:function
|
tumor suppressor
phosphatase activity
|
|
gptkbp:geneGroup
|
gptkb:Phosphatases
Tumor suppressors
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:10680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:10680
|
|
gptkbp:isProteinCoding
|
true
|
|
gptkbp:isTumorSuppressor
|
true
|
|
gptkbp:length
|
403 amino acids
|
|
gptkbp:locatedOnChromosome
|
10
chr10:87863119-87971930 (GRCh38)
|
|
gptkbp:location
|
gptkb:10q23.31
|
|
gptkbp:locusType
|
gene with protein product
|
|
gptkbp:OMIM
|
601728
|
|
gptkbp:orthologIn
|
gptkb:rat:Pten
gptkb:zebrafish:ptena
gptkb:zebrafish:ptenb
mouse:Pten
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
apoptosis
cell proliferation
cell cycle regulation
cell migration
|
|
gptkbp:previousSymbols
|
gptkb:MMAC1
gptkb:TEP1
|
|
gptkbp:product
|
gptkb:PTEN_protein
|
|
gptkbp:proteinFamily
|
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:RefSeq
|
gptkb:NM_000314
|
|
gptkbp:strand
|
minus
|
|
gptkbp:symbol
|
approved
|
|
gptkbp:UniProtID
|
gptkb:P60484
|
|
gptkbp:bfsParent
|
gptkb:SDHA
|
|
gptkbp:bfsLayer
|
7
|