phosphatase and tensin homolog deleted on chromosome 10

URI: https://gptkb.org/entity/phosphatase_and_tensin_homolog_deleted_on_chromosome_10
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:abbreviation gptkb:PTEN
gptkbp:biologicalProcess protein tyrosine phosphatase activity
lipid phosphatase activity
gptkbp:cellularComponent gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
gptkbp:discoveredBy gptkb:Paula_S._Meltzer
gptkbp:discoveredIn 1997
gptkbp:encodedBy gptkb:PTEN_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000171862
5728
gptkbp:expressedIn many tissues
gptkbp:function tumor suppressor
phosphatase activity
gptkbp:HGNC_ID 9588
https://www.w3.org/2000/01/rdf-schema#label phosphatase and tensin homolog deleted on chromosome 10
gptkbp:inhibitedBy gptkb:PI3K/AKT_signaling_pathway
gptkbp:locatedOnChromosome gptkb:chromosome_10
gptkbp:mutationAssociatedWith gptkb:Bannayan–Riley–Ruvalcaba_syndrome
gptkb:Lhermitte–Duclos_disease
gptkb:cancer
gptkb:Cowden_syndrome
gptkbp:OMIM 601728
gptkbp:orthologInMouse Pten
gptkbp:orthologInZebrafish ptena
ptenb
gptkbp:regulates gptkb:synaptic_plasticity
apoptosis
cell proliferation
DNA repair
metabolism
cellular senescence
angiogenesis
cell migration
glucose metabolism
immune response
cell cycle
neuronal development
autophagy
axon regeneration
cellular growth
stem cell self-renewal
cellular survival
gptkbp:relatedTo gptkb:PTEN_hamartoma_tumor_syndrome
gptkbp:UniProtID gptkb:P60484
gptkbp:bfsParent gptkb:HGNC:11050
gptkbp:bfsLayer 7