phosphatase and tensin homolog deleted on chromosome 10

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:gene
gptkbp:abbreviation	gptkb:PTEN
gptkbp:biologicalProcess	protein tyrosine phosphatase activity lipid phosphatase activity
gptkbp:cellularComponent	gptkb:cell_membrane gptkb:nucleus gptkb:cytoplasm
gptkbp:discoveredBy	gptkb:Paula_S._Meltzer
gptkbp:discoveredIn	1997
gptkbp:encodedBy	gptkb:PTEN_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000171862 5728
gptkbp:expressedIn	many tissues
gptkbp:function	gptkb:tumor_suppressor phosphatase activity
gptkbp:HGNC_ID	9588
gptkbp:inhibitedBy	gptkb:PI3K/AKT_signaling_pathway
gptkbp:locatedOnChromosome	gptkb:chromosome_10
gptkbp:mutationAssociatedWith	gptkb:Bannayan–Riley–Ruvalcaba_syndrome gptkb:Lhermitte–Duclos_disease gptkb:cancer gptkb:Cowden_syndrome
gptkbp:OMIM	601728
gptkbp:orthologInMouse	Pten
gptkbp:orthologInZebrafish	ptena ptenb
gptkbp:regulates	gptkb:immune_response gptkb:synaptic_plasticity apoptosis cell proliferation DNA repair metabolism cellular senescence angiogenesis cell migration glucose metabolism cell cycle neuronal development autophagy axon regeneration cellular growth stem cell self-renewal cellular survival
gptkbp:relatedTo	gptkb:PTEN_hamartoma_tumor_syndrome
gptkbp:UniProtID	gptkb:P60484
gptkbp:bfsParent	gptkb:HGNC:11050
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	phosphatase and tensin homolog deleted on chromosome 10