|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
ligand binding
|
|
gptkbp:alsoKnownAs
|
gptkb:ERBB2
human epidermal growth factor receptor 2
|
|
gptkbp:clinicalTrialPhase
|
gptkb:FISH
gptkb:CISH
immunohistochemistry
SISH
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:ERBB2_gene
|
|
gptkbp:expressedIn
|
epithelial cells
|
|
gptkbp:form
|
heterodimers
homodimers
|
|
gptkbp:formsHeterodimerWith
|
gptkb:EGFR
gptkb:HER3
gptkb:HER4
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:HGNC_ID
|
3430
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HER2 protein
|
|
gptkbp:involvedIn
|
cell differentiation
cell growth
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
gptkb:17q12
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
epidermal growth factor receptor family
|
|
gptkbp:molecularWeight
|
185 kDa
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
|
|
gptkbp:OMIM
|
164870
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
gastric cancer
|
|
gptkbp:PDB
|
3PP0
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:RefSeq
|
NP_004439.2
|
|
gptkbp:role
|
oncogenesis
|
|
gptkbp:structure
|
transmembrane glycoprotein
|
|
gptkbp:target
|
gptkb:ado-trastuzumab_emtansine
gptkb:pertuzumab
gptkb:trastuzumab
gptkb:lapatinib
|
|
gptkbp:targetOfDrug
|
gptkb:ado-trastuzumab_emtansine
gptkb:pertuzumab
gptkb:trastuzumab
gptkb:tucatinib
gptkb:lapatinib
gptkb:neratinib
fam-trastuzumab deruxtecan
|
|
gptkbp:therapeuticBiomarkerFor
|
gptkb:cancer
gastric cancer
|
|
gptkbp:UniProtID
|
gptkb:P04626
|
|
gptkbp:bfsParent
|
gptkb:triple-negative_breast_cancer
|
|
gptkbp:bfsLayer
|
6
|