|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:E6-associated_protein
gptkb:UBE3A
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:autism_spectrum_disorder
gptkb:Angelman_syndrome
|
|
gptkbp:biologicalProcess
|
protein degradation
neurodevelopment
synaptic function
|
|
gptkbp:discoveredBy
|
Huibregtse JM et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:domain
|
gptkb:HECT_domain
|
|
gptkbp:encodedBy
|
gptkb:UBE3A_gene
|
|
gptkbp:Entrez_Gene_ID
|
7337
|
|
gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
|
|
gptkbp:interactsWith
|
gptkb:HPV_E6_protein
|
|
gptkbp:involvedIn
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:15q11-q13
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Angelman_syndrome
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:right
gptkb:zebrafish
|
|
gptkbp:postTranslationalModification
|
ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:HECT_domain_E3_ligases
|
|
gptkbp:species
|
gptkb:human
|
|
gptkbp:UniProtID
|
gptkb:Q05086
|
|
gptkbp:bfsParent
|
gptkb:UBE3A
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
E6-AP
|