Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:class |
HECT-type E3 ligases
RBR-type E3 ligases RING-type E3 ligases |
| gptkbp:contains |
gptkb:HECT_domain
RING finger domain U-box domain |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurodegenerative diseases autoimmune diseases |
| gptkbp:example |
gptkb:APC/C
gptkb:MDM2 gptkb:Parkin gptkb:c-Cbl SCF complex TRIM family |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
catalyze transfer of ubiquitin to substrate proteins
|
| https://www.w3.org/2000/01/rdf-schema#label |
E3 ubiquitin ligases
|
| gptkbp:involvedIn |
ubiquitin-proteasome system
|
| gptkbp:medium |
monoubiquitination
polyubiquitination multi-monoubiquitination |
| gptkbp:numberOfGenes |
over 600
|
| gptkbp:regulates |
apoptosis
cell differentiation signal transduction DNA repair metabolism transcription factors inflammation immune response cell cycle protein degradation protein-protein interactions cell signaling pathways cellular stress response developmental processes chromatin remodeling protein stability receptor downregulation cellular localization of proteins |
| gptkbp:requires |
gptkb:E2_ubiquitin-conjugating_enzyme
protein homeostasis |
| gptkbp:target |
therapeutic drugs
specific substrate proteins |
| gptkbp:bfsParent |
gptkb:HECT_domain
|
| gptkbp:bfsLayer |
7
|