Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:catalyzes |
ubiquitin transfer to substrate proteins
|
| gptkbp:discoveredBy |
1995
|
| gptkbp:domain |
gptkb:HECT_domain
|
| gptkbp:example |
gptkb:E6AP
gptkb:ITCH gptkb:NEDD4 gptkb:SMURF1 gptkb:SMURF2 gptkb:WWP1 gptkb:WWP2 gptkb:HUWE1 |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
ubiquitin ligase activity
|
| https://www.w3.org/2000/01/rdf-schema#label |
HECT-type ubiquitin ligase
|
| gptkbp:interactsWith |
gptkb:E2_ubiquitin-conjugating_enzyme
|
| gptkbp:involves |
protein ubiquitination
|
| gptkbp:mechanismOfAction |
forms thioester intermediate with ubiquitin
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
neurodevelopmental disorders |
| gptkbp:name_stands_for |
Homologous to E6AP C-Terminus
|
| gptkbp:regulates |
cell signaling
cell cycle protein degradation |
| gptkbp:bfsParent |
gptkb:ubiquitin_ligase
|
| gptkbp:bfsLayer |
7
|