|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:GSK-3_alpha
gptkb:glycogen_synthase_kinase_3_alpha
GSK3 alpha
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:GSK3A_gene
|
|
gptkbp:Entrez_Gene_ID
|
2931
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.26
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
liver
|
|
gptkbp:fullName
|
gptkb:Glycogen_synthase_kinase-3_alpha
|
|
gptkbp:function
|
serine/threonine protein kinase
|
|
gptkbp:hasParalog
|
GSK3B protein
|
|
gptkbp:HGNC_ID
|
4616
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GSK3A protein
|
|
gptkbp:inhibitedBy
|
gptkb:SB-216763
gptkb:CHIR99021
lithium
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
glycogen metabolism
insulin signaling pathway
|
|
gptkbp:length
|
483 amino acids
|
|
gptkbp:locatedOnChromosome
|
19q13.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
51 kDa
|
|
gptkbp:OMIM
|
606784
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Gsk3a protein
rat Gsk3a protein
|
|
gptkbp:PDB
|
gptkb:1Q4L
|
|
gptkbp:phosphorylates
|
Ser21
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
NP_063937.2
|
|
gptkbp:regulates
|
activated by dephosphorylation
inhibited by phosphorylation at Ser21
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
contains protein kinase domain
|
|
gptkbp:substrate
|
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
|
|
gptkbp:UniProtID
|
gptkb:P49840
|
|
gptkbp:bfsParent
|
gptkb:19q13.2_(GSK3A)
|
|
gptkbp:bfsLayer
|
7
|