|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:GSK3A
gptkb:glycogen_synthase_kinase_3_alpha
serine/threonine-protein kinase GSK3A
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
gptkb:GSK3A_gene
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.26
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
|
|
gptkbp:fullName
|
gptkb:Glycogen_synthase_kinase-3_alpha
|
|
gptkbp:function
|
serine/threonine protein kinase
regulation of glycogen metabolism
regulation of cell signaling
|
|
gptkbp:gene
|
gptkb:GSK3A
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GSK-3 alpha
|
|
gptkbp:inhibitedBy
|
lithium
ATP-competitive inhibitors
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
apoptosis
cell proliferation
neurogenesis
insulin signaling pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19q13.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
51 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Gsk3a
|
|
gptkbp:PDB
|
gptkb:1Q4L
|
|
gptkbp:phosphorylates
|
Ser21
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:glycogen_synthase
transcription factors
microtubule-associated proteins
|
|
gptkbp:relatedTo
|
gptkb:GSK-3_beta
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
|
|
gptkbp:structureType
|
monomer
|
|
gptkbp:UniProtID
|
gptkb:P49840
|
|
gptkbp:bfsParent
|
gptkb:GSK3A
|
|
gptkbp:bfsLayer
|
7
|