GRB2-associated binding protein 2

URI: https://gptkb.org/entity/GRB2-associated_binding_protein_2
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:GAB2
GRB2-associated binder 2
GRB2-associated binding protein 2, 100kDa
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:cancer
leukemia
gptkbp:domain gptkb:PH_domain
proline-rich region
multiple tyrosine phosphorylation sites
gptkbp:Entrez_Gene_ID 9846
gptkbp:firstDescribed 1999
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function signal transduction
scaffolding protein
gptkbp:gene gptkb:GAB2
gptkbp:geneType protein-coding
https://www.w3.org/2000/01/rdf-schema#label GRB2-associated binding protein 2
gptkbp:interactsWith gptkb:PTPN11
gptkb:SHC1
gptkb:PI3K
gptkb:GRB2
gptkb:CRK
SH2 domain-containing proteins
gptkbp:involves gptkb:PI3K-Akt_signaling_pathway
insulin signaling pathway
EGF receptor signaling pathway
gptkbp:locatedOnChromosome chromosome 11
11q14.1
gptkbp:location gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:molecularWeight ~100 kDa
gptkbp:OMIM 606203
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:phosphorylates tyrosine residues
tyrosine kinases
serine residues
threonine residues
gptkbp:postTranslationalModification phosphorylation
gptkbp:regulates cell differentiation
cell proliferation
cell survival
cell migration
gptkbp:UniProtID Q9UQC2
gptkbp:bfsParent gptkb:GAB2
gptkbp:bfsLayer 6