Growth Differentiation Factor 15

URI: https://gptkb.org/entity/Growth_Differentiation_Factor_15
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:MIC-1
gptkb:GDF15
macrophage inhibitory cytokine-1
placental bone morphogenetic protein
gptkbp:associatedWith gptkb:metabolic_syndrome
obesity
anorexia
cachexia
gptkbp:discoveredBy multiple research groups in late 1990s
gptkbp:encodedBy GDF15 gene
gptkbp:Entrez_Gene_ID 9518
gptkbp:expressedIn gptkb:placenta
gptkb:prostate
liver
macrophages
gptkbp:function cellular response to stress
regulation of appetite
regulation of energy homeostasis
regulation of inflammatory and apoptotic pathways
gptkbp:hasBiomarker gptkb:cancer
gptkb:cardiovascular_disease
kidney disease
gptkbp:HGNC_ID HGNC:4225
https://www.w3.org/2000/01/rdf-schema#label Growth Differentiation Factor 15
gptkbp:improves gptkb:cancer
heart failure
chronic kidney disease
inflammation
tissue injury
gptkbp:locatedOnChromosome chromosome 19p13.11
gptkbp:memberOf gptkb:transforming_growth_factor_beta_superfamily
gptkbp:molecularWeight ~25 kDa (mature form)
gptkbp:OMIM 605312
gptkbp:orthologIn gptkb:mouse
gptkb:zebrafish
right
gptkbp:PDB 5LW5
gptkbp:postTranslationalModification glycosylation
proteolytic cleavage
gptkbp:recipient gptkb:GFRAL
gptkbp:regulates apoptosis
cell proliferation
inflammatory response
body weight
food intake
gptkbp:secretes various tissues including liver, placenta, and prostate
gptkbp:structure homodimer
gptkbp:UniProtID gptkb:Q99988
gptkbp:bfsParent gptkb:GDF15
gptkbp:bfsLayer 7