Frizzled family receptors

URI: https://gptkb.org/entity/Frizzled_family_receptors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:Frizzled_receptors gptkb:FZD_receptors Fzds
gptkbp:associatedWith	gptkb:retinal_vascular_disease colorectal cancer bone density disorders
gptkbp:contains	gptkb:Frizzled-1 gptkb:Frizzled-10 gptkb:Frizzled-2 gptkb:Frizzled-3 gptkb:Frizzled-4 gptkb:Frizzled-5 gptkb:Frizzled-6 gptkb:Frizzled-7 gptkb:Frizzled-8 gptkb:Frizzled-9
gptkbp:discoveredIn	1990s
gptkbp:domain	cysteine-rich domain (CRD)
gptkbp:encodedBy	gptkb:FZD1 gptkb:FZD10 gptkb:FZD2 gptkb:FZD3 gptkb:FZD4 gptkb:FZD5 gptkb:FZD6 gptkb:FZD7 gptkb:FZD8 gptkb:FZD9
gptkbp:function	Wnt signaling pathway receptor
https://www.w3.org/2000/01/rdf-schema#label	Frizzled family receptors
gptkbp:interactsWith	gptkb:Dishevelled_proteins gptkb:LRP5/6
gptkbp:involvedIn	gptkb:cancer cell proliferation embryonic development stem cell maintenance cell polarity tissue homeostasis
gptkbp:ligand	gptkb:Wnt_proteins
gptkbp:location	gptkb:cell_membrane
gptkbp:modulatedBy	gptkb:WIF-1 Dickkopf proteins (DKKs) secreted Frizzled-related proteins (sFRPs)
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Homo_sapiens gptkb:Drosophila_melanogaster
gptkbp:proteinFamily	gptkb:FZD_genes
gptkbp:relatedTo	gptkb:G_protein-coupled_receptors
gptkbp:structure	seven transmembrane domains
gptkbp:bfsParent	gptkb:Wnt_proteins
gptkbp:bfsLayer	7