Fms-like tyrosine kinase 3

URI: https://gptkb.org/entity/Fms-like_tyrosine_kinase_3
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:CD135
FLK2
STK1
FLK-2
gptkbp:associatedWith gptkb:acute_myeloid_leukemia
gptkbp:biologicalProcess cell differentiation
cell proliferation
signal transduction
ATP binding
protein kinase activity
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:discoveredBy 1991
gptkbp:encodedBy gptkb:FLT3_gene
gptkbp:Entrez_Gene_ID 2322
gptkbp:expressedIn hematopoietic progenitor cells
gptkbp:function gptkb:receptor_tyrosine_kinase
cell signaling
hematopoiesis regulation
gptkbp:gene gptkb:FLT3
gptkbp:geneType protein-coding
gptkbp:HGNC_ID 3765
https://www.w3.org/2000/01/rdf-schema#label Fms-like tyrosine kinase 3
gptkbp:ligand FLT3 ligand
gptkbp:locatedOnChromosome gptkb:13q12
gptkb:chromosome_13
gptkbp:mutationAssociatedWith point mutation
constitutive activation
leukemogenesis
internal tandem duplication
gptkbp:OMIM 136351
gptkbp:orthologInMouse Flt3
gptkbp:PDB 4RT7
4XUF
6JQR
gptkbp:phosphorylates tyrosine residue
gptkbp:proteinFamily class III receptor tyrosine kinase family
gptkbp:reviewedBy gptkb:Nature_Reviews_Cancer
gptkb:Blood
gptkbp:significance prognostic marker in AML
gptkbp:structure extracellular domain
transmembrane domain
intracellular kinase domain
gptkbp:targetOfDrug gptkb:gilteritinib
gptkb:quizartinib
gptkb:midostaurin
gptkbp:transmembraneDomains true
gptkbp:UniProtID P36888
gptkbp:bfsParent gptkb:FLT3
gptkbp:bfsLayer 7