|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
FGF-21
fibroblast growth factor 21
|
|
gptkbp:clinicalTrialPhase
|
Efruxifermin
Pegbelfermin
|
|
gptkbp:cofactor
|
beta-Klotho
|
|
gptkbp:discoveredBy
|
Nishimura et al.
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodedBy
|
FGF21 gene
|
|
gptkbp:Entrez_Gene_ID
|
26291
|
|
gptkbp:expressedIn
|
liver
adipose tissue
pancreas
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
Fibroblast growth factor 21
|
|
gptkbp:function
|
regulation of lipid metabolism
hormone activity
regulation of glucose uptake
regulation of energy expenditure
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGF21
|
|
gptkbp:locatedOnChromosome
|
gptkb:19q13.33_(human)
|
|
gptkbp:memberOf
|
gptkb:fibroblast_growth_factor_family
|
|
gptkbp:molecularWeight
|
22.5 kDa (human)
|
|
gptkbp:OMIM
|
609436
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:PDB
|
5VAQ
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:recipient
|
gptkb:FGFR3
gptkb:FGFR1
gptkb:FGFR2
|
|
gptkbp:regulates
|
gptkb:glucagon
gptkb:insulin
gptkb:ketogenic_diet
fasting
recombinant human growth hormone
PPAR-alpha
|
|
gptkbp:relatedTo
|
gptkb:type_2_diabetes
gptkb:non-alcoholic_fatty_liver_disease
gptkb:metabolic_syndrome
obesity
|
|
gptkbp:secretes
|
yes
|
|
gptkbp:sequence
|
209 amino acids (human)
|
|
gptkbp:structureType
|
single-chain polypeptide
|
|
gptkbp:targetOfDrug
|
metabolic disorders
|
|
gptkbp:UniProtID
|
Q9NSA1
|
|
gptkbp:bfsParent
|
gptkb:CD331
|
|
gptkbp:bfsLayer
|
7
|