|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
cell surface receptor
|
|
gptkbp:alsoKnownAs
|
gptkb:APO-1
gptkb:CD95
gptkb:TNFRSF6
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:domain
|
death domain
|
|
gptkbp:EC_number
|
none
|
|
gptkbp:encodedBy
|
gptkb:FAS_gene
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
induces apoptosis
|
|
gptkbp:hasCytoplasmicDomain
|
yes
|
|
gptkbp:hasDisulfideBonds
|
yes
|
|
gptkbp:hasExtracellularDomain
|
yes
|
|
gptkbp:hasGlycosylationSites
|
yes
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11920
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FAS receptor
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:caspase-8
FAS ligand
|
|
gptkbp:involvedIn
|
gptkb:liver_disease
cancer biology
inflammation
programmed cell death
neurodegeneration
autoimmunity
immune system regulation
|
|
gptkbp:ligand
|
FAS ligand
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
gptkb:10q23.31
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:molecularWeight
|
~48 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome
impaired apoptosis
|
|
gptkbp:OMIM
|
134637
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:3THM
|
|
gptkbp:regulates
|
cell survival
immune cell homeostasis
|
|
gptkbp:signalPeptide
|
yes
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
gptkb:P25445
|
|
gptkbp:bfsParent
|
gptkb:PTPN13
|
|
gptkbp:bfsLayer
|
7
|