Enhancer of zeste homolog 2 protein

URI: https://gptkb.org/entity/Enhancer_of_zeste_homolog_2_protein
GPTKB entity
Statements (41)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alias gptkb:EZH2
gptkb:ENX1
gptkb:KMT6
gptkbp:associatedWith gptkb:cancer
gene silencing
epigenetic regulation
gptkbp:catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3)
gptkbp:component gptkb:Polycomb_Repressive_Complex_2_(PRC2)
gptkbp:domain gptkb:CXC_domain
gptkb:SANT_domain
SET domain
gptkbp:encodedBy gptkb:EZH2_gene
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function histone methyltransferase
https://www.w3.org/2000/01/rdf-schema#label Enhancer of zeste homolog 2 protein
gptkbp:length 751 amino acids
gptkbp:locatedOnChromosome 7q36.1
gptkbp:molecularWeight 85 kDa
gptkbp:mutationAssociatedWith gptkb:Weaver_syndrome
myeloid malignancies
gptkbp:OMIM 601573
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Drosophila_melanogaster_(E(z))
gptkbp:overexpressedIn gptkb:cancer
leukemia
prostate cancer
gptkbp:PDB gptkb:5HYN
5IJ7
gptkbp:regulates differentiation
cell cycle
stem cell pluripotency
gptkbp:reviewedBy gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
gptkbp:target gptkb:tazemetostat
EZH2 inhibitors
gptkbp:UniProtID gptkb:Q15910
gptkbp:bfsParent gptkb:EZH2_gene
gptkb:EZH2_gene_(human)
gptkbp:bfsLayer 8