Enhancer of zeste homolog 2 protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alias	gptkb:EZH2 gptkb:ENX1 gptkb:KMT6
gptkbp:associatedWith	gptkb:cancer gene silencing epigenetic regulation
gptkbp:catalyzes	trimethylation of histone H3 at lysine 27 (H3K27me3)
gptkbp:component	gptkb:Polycomb_Repressive_Complex_2_(PRC2)
gptkbp:domain	gptkb:CXC_domain gptkb:SANT_domain SET domain
gptkbp:encodedBy	gptkb:EZH2_gene
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	histone methyltransferase
gptkbp:length	751 amino acids
gptkbp:locatedOnChromosome	7q36.1
gptkbp:molecularWeight	85 kDa
gptkbp:mutationAssociatedWith	gptkb:Weaver_syndrome myeloid malignancies
gptkbp:OMIM	601573
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Drosophila_melanogaster_(E(z))
gptkbp:overexpressedIn	gptkb:leukemia gptkb:cancer prostate cancer
gptkbp:PDB	gptkb:5HYN 5IJ7
gptkbp:regulates	differentiation cell cycle stem cell pluripotency
gptkbp:reviewedBy	gptkb:GeneCards gptkb:NCBI_Gene gptkb:UniProt
gptkbp:target	gptkb:tazemetostat EZH2 inhibitors
gptkbp:UniProtID	gptkb:Q15910
gptkbp:bfsParent	gptkb:EZH2_gene gptkb:EZH2_gene_(human)
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	Enhancer of zeste homolog 2 protein