|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BCC7
gptkb:LFS1
gptkb:TRP53
P53
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
|
|
gptkbp:biologicalProcess
|
DNA damage response
apoptotic process
cell cycle arrest
protein binding
DNA-binding transcription factor activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:describes
|
gptkb:tumor_protein_p53
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:domain
|
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscript
|
gptkb:ENST00000269305
|
|
gptkbp:HGNC_ID
|
11998
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ENSG00000141552
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17
17p13.1
|
|
gptkbp:molecularWeight
|
43.7 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased cancer risk
loss of tumor suppression
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Trp53
gptkb:zebrafish_tp53
|
|
gptkbp:partOf
|
p53 signaling pathway
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:ARF
gptkb:MDM2
gptkb:CHK2
apoptosis
ATM
DNA repair
senescence
cell cycle arrest
|
|
gptkbp:UniProtID
|
gptkb:ENSP00000269305
P04637
|
|
gptkbp:bfsParent
|
gptkb:LGP2
gptkb:DHX2
|
|
gptkbp:bfsLayer
|
7
|