|
gptkbp:instanceOf
|
Ensembl gene ID
|
|
gptkbp:alias
|
gptkb:p53
gptkb:BCC7
gptkb:LFS1
gptkb:TRP53
P53
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
colorectal cancer
bladder cancer
adrenocortical carcinoma
osteosarcoma
|
|
gptkbp:encodes
|
gptkb:TP53
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:essentialGene
|
true
|
|
gptkbp:function
|
tumor suppressor
transcription factor
genome stability
apoptosis regulation
cell cycle arrest
DNA binding
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:geneType
|
protein_coding
|
|
gptkbp:hasParalog
|
gptkb:TP73
gptkb:TP63
|
|
gptkbp:hasTranscript
|
gptkb:ENST00000269305
ENST00000413465
ENST00000420246
ENST00000445888
|
|
gptkbp:HGNC_ID
|
HGNC:11998
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ENSG00000141448
|
|
gptkbp:isFrequentlyMutatedIn
|
human cancers
|
|
gptkbp:locatedOnChromosome
|
17
17p13.1
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
ENSMUSG00000059552
ENSDARG00000039062
|
|
gptkbp:pathway
|
apoptosis
cell cycle
senescence
DNA damage response
p53 signaling pathway
|
|
gptkbp:product
|
gptkb:cellular_tumor_antigen_p53
|
|
gptkbp:referenceGenome
|
gptkb:GRCh37
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:ATR
gptkb:CHEK2
gptkb:TP53INP1
ATM
HIPK2
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:target
|
gptkb:MDM2
gptkb:MDM4
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:Bip_(gene)
|
|
gptkbp:bfsLayer
|
6
|