Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:catalyzes |
transfer of ubiquitin from E2 to substrate
|
| gptkbp:conservedIn |
cysteine
|
| gptkbp:domain |
gptkb:HECT_domain
|
| gptkbp:enzymeCommissionNumber |
EC 2.3.2.27
|
| gptkbp:firstDescribed |
1995
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
ubiquitin ligase activity
|
| gptkbp:hasSubfamilies |
HERC family
NEDD4 family other HECT E3s |
| https://www.w3.org/2000/01/rdf-schema#label |
HECT domain E3 ligases
|
| gptkbp:includes |
gptkb:E6AP
gptkb:ITCH gptkb:NEDD4 gptkb:SMURF1 |
| gptkbp:involvedIn |
ubiquitination
|
| gptkbp:involves |
gptkb:cancer
gptkb:virus neurodegenerative diseases |
| gptkbp:memberOf |
gptkb:E3_ubiquitin_ligases
|
| gptkbp:regulates |
protein degradation
|
| gptkbp:bfsParent |
gptkb:E3_ubiquitin-protein_ligase
|
| gptkbp:bfsLayer |
7
|