endoplasmic reticulum-associated degradation (ERAD)
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:abbreviation |
ERAD
|
| gptkbp:discoveredBy |
1990s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:diabetes
neurodegenerative diseases cystic fibrosis |
| gptkbp:function |
protein quality control
removal of misfolded proteins |
| https://www.w3.org/2000/01/rdf-schema#label |
endoplasmic reticulum-associated degradation (ERAD)
|
| gptkbp:involves |
gptkb:OS-9
gptkb:E3_ubiquitin_ligases ubiquitination ubiquitin-proteasome system chaperone proteins proteasomal degradation deubiquitination HRD1 SEL1L XTP3-B derlin proteins p97/VCP ATPase retrotranslocation |
| gptkbp:occurredIn |
gptkb:endoplasmic_reticulum
|
| gptkbp:regulates |
endoplasmic reticulum homeostasis
|
| gptkbp:relatedTo |
unfolded protein response
|
| gptkbp:studiedBy |
gptkb:yeast
mammalian cells |
| gptkbp:bfsParent |
gptkb:p97/VCP
|
| gptkbp:bfsLayer |
7
|