|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
Dishevelled 2
Dsh homolog 2
|
|
gptkbp:associatedWith
|
gptkb:DVL1_gene
gptkb:DVL3_gene
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
DVL2 protein
|
|
gptkbp:Entrez_Gene_ID
|
1856
ENSG00000107518
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:fullName
|
Dishevelled Segment Polarity Protein 2
|
|
gptkbp:function
|
embryonic development
signal transduction
cell proliferation regulation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:3085
|
|
gptkbp:interactsWith
|
gptkb:APC_protein
gptkb:Frizzled_receptors
gptkb:GSK3B
gptkb:AXIN1
CSNK1E
Dishevelled-associated proteins
|
|
gptkbp:length
|
~7.5 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurodevelopmental disorders
|
|
gptkbp:numberOfExons
|
15
|
|
gptkbp:OMIM
|
602151
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInFruitFly
|
dsh
|
|
gptkbp:orthologInMouse
|
Dvl2
|
|
gptkbp:orthologInZebrafish
|
dvl2a
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:proteinFamily
|
gptkb:DIX_domain
DEP domain
PDZ domain
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
beta-catenin signaling
planar cell polarity pathway
|
|
gptkbp:relatedTo
|
Dishevelled gene family
|
|
gptkbp:significance
|
potential biomarker in cancer
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:symbol
|
gptkb:DVL2
|
|
gptkbp:UniProtID
|
O14641
|
|
gptkbp:bfsParent
|
gptkb:Dishevelled
|
|
gptkbp:bfsLayer
|
7
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
DVL2 gene
|