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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:DNMT
gptkb:cytosine-5-methyltransferase
|
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gptkbp:associatedWith
|
gptkb:cancer
gptkb:Rett_syndrome
immunodeficiency
|
|
gptkbp:biologicalProcess
|
gptkb:X-chromosome_inactivation
gene silencing
epigenetic regulation
genomic imprinting
|
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gptkbp:cofactor
|
gptkb:S-adenosyl_methionine
|
|
gptkbp:discoveredBy
|
gptkb:Arthur_Kornberg
|
|
gptkbp:EC_number
|
2.1.1.37
|
|
gptkbp:firstDescribed
|
1950s
|
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gptkbp:foundIn
|
prokaryotes
eukaryotes
|
|
gptkbp:function
|
catalyzes transfer of methyl group to DNA
|
|
gptkbp:gene
|
gptkb:DNMT1
gptkb:DNMT2
gptkb:DNMT3A
gptkb:DNMT3B
gptkb:DNMT3L
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNA methyltransferase
|
|
gptkbp:inhibitedBy
|
gptkb:5-azacytidine
gptkb:decitabine
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:methylation_context
|
gptkb:CpG_dinucleotide
non-CpG sites
|
|
gptkbp:methylation_site
|
adenine
cytosine
|
|
gptkbp:orthologIn
|
gptkb:Bacteria
animals
plants
archaea
|
|
gptkbp:product
|
methylated DNA
|
|
gptkbp:role
|
cell differentiation
embryogenesis
maintenance of DNA methylation patterns
|
|
gptkbp:structure
|
contains regulatory domain
contains catalytic domain
|
|
gptkbp:substrate
|
gptkb:gene
|
|
gptkbp:type
|
gptkb:DNMT1
gptkb:DNMT2
gptkb:DNMT3A
gptkb:DNMT3B
gptkb:DNMT3L
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|