|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Protein_deglycase_DJ-1
gptkb:PARK7_protein
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
|
|
gptkbp:biologicalProcess
|
regulation of transcription
response to oxidative stress
cellular protection
protein deglycation
|
|
gptkbp:discoveredBy
|
gptkb:Nagakubo_et_al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:diseaseBiomarkerFor
|
gptkb:Parkinson's_disease
|
|
gptkbp:encodedBy
|
gptkb:PARK7_gene
|
|
gptkbp:Entrez_Gene_ID
|
11315
|
|
gptkbp:enzyme
|
yes
deglycase
|
|
gptkbp:enzymeCommissionNumber
|
EC 3.5.1.-
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
acts as a redox-sensitive chaperone
deglycase activity
protects cells against oxidative stress
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DJ-1 protein
|
|
gptkbp:interactsWith
|
gptkb:alpha-synuclein
gptkb:Hsp70
gptkb:PINK1_protein
LRRK2 protein
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.23
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
20 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:early-onset_Parkinson's_disease
loss of function
mitochondrial dysfunction
increased oxidative stress sensitivity
|
|
gptkbp:OMIM
|
602533
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
1P5F
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
sumoylation
|
|
gptkbp:sequence
|
189 amino acids
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subcellularLocation
|
nucleolus
cytosol
mitochondrial matrix
|
|
gptkbp:UniProtID
|
Q99497
|
|
gptkbp:bfsParent
|
gptkb:DJ-1_gene
gptkb:PARK7_gene
|
|
gptkbp:bfsLayer
|
8
|