|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:DEAD-box_helicases
|
|
gptkbp:category
|
gptkb:ATPases
RNA-binding proteins
|
|
gptkbp:conservedIn
|
DEAD (Asp-Glu-Ala-Asp)
|
|
gptkbp:contains
|
gptkb:DDX17
gptkb:DDX21
gptkb:DDX3
gptkb:DDX39
gptkb:DDX41
gptkb:DDX5
gptkb:DDX58
gptkb:DDX6
gptkb:DDX_proteins
gptkb:Dbp5
gptkb:Dbp_proteins
gptkb:eIF4A
|
|
gptkbp:database
|
gptkb:InterPro:_IPR014001
gptkb:MEROPS:_clan_SF2
gptkb:PROSITE:_PS51192
gptkb:Pfam:_PF00270
|
|
gptkbp:discoveredBy
|
Linder et al.
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:foundIn
|
prokaryotes
eukaryotes
|
|
gptkbp:function
|
ATP-dependent RNA unwinding
RNA helicase activity
|
|
gptkbp:GO_term
|
GO:0003724 (RNA helicase activity)
GO:0004386 (helicase activity)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DEAD box protein family
|
|
gptkbp:involvedIn
|
cell division
cell growth
embryogenesis
spermatogenesis
|
|
gptkbp:motif
|
Asp-Glu-Ala-Asp (DEAD) sequence
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurological disorders
infertility
|
|
gptkbp:numberOfMembers
|
~37 in humans
|
|
gptkbp:relatedTo
|
gptkb:DEAH_box_protein_family
gptkb:RNA_helicase_superfamily_2
|
|
gptkbp:role
|
splicing
translation initiation
RNA transport
RNA metabolism
ribosome assembly
RNA decay
|
|
gptkbp:uniprotCategory
|
gptkb:DEAD_box_proteins
|
|
gptkbp:bfsParent
|
gptkb:LGP2
|
|
gptkbp:bfsLayer
|
7
|