|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Retinoic_acid-inducible_gene_I
RIGI
|
|
gptkbp:alternativeName
|
gptkb:RIG-I
DEAD box polypeptide 58
|
|
gptkbp:associatedWith
|
interferon signaling
antiviral response
|
|
gptkbp:component
|
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
Takashi Fujita
|
|
gptkbp:discoveredIn
|
2004
|
|
gptkbp:encodes
|
RIG-I protein
|
|
gptkbp:Entrez_Gene_ID
|
23586
ENSG00000107201
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
ATP-dependent RNA helicase activity
innate immune response
viral RNA recognition
|
|
gptkbp:GOProcess
|
defense response to virus
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DDX58
|
|
gptkbp:interactsWith
|
gptkb:MAVS
gptkb:TRIM25
viral RNA
|
|
gptkbp:length
|
925 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9
|
|
gptkbp:molecularWeight
|
approximately 106 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Singleton-Merten_syndrome
autoimmune diseases
|
|
gptkbp:OMIM
|
609631
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ddx58
|
|
gptkbp:PDB
|
5F9H
5JCT
|
|
gptkbp:phosphorylates
|
Ser8
Thr170
|
|
gptkbp:proteinFamily
|
gptkb:DEAD_box_protein_family
gptkb:CARD_domain
helicase domain
C-terminal regulatory domain
|
|
gptkbp:regulates
|
type I interferon production
induced by interferon
upregulated by viral infection
|
|
gptkbp:significance
|
autoimmune disorders
viral infection susceptibility
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
mitochondrial membrane
|
|
gptkbp:UniProtID
|
gptkb:O95786
|
|
gptkbp:bfsParent
|
gptkb:DEAD_box_protein_family
gptkb:Laboratory_of_Genetics_and_Physiology_2
gptkb:RIG-I
|
|
gptkbp:bfsLayer
|
8
|