Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
DEAD-box proteins
|
| gptkbp:discoveredBy |
Linder et al.
|
| gptkbp:example |
gptkb:DDX21
gptkb:DDX41 gptkb:DDX5 gptkb:DDX58 gptkb:DDX6 gptkb:eIF4A DDX3X |
| gptkbp:firstDescribed |
1989
|
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| gptkbp:function |
RNA helicase activity
|
| gptkbp:GO_term |
GO:0004386
|
| https://www.w3.org/2000/01/rdf-schema#label |
DEAD-box helicases
|
| gptkbp:involves |
splicing
ribosome biogenesis translation initiation RNA transport RNA metabolism RNA decay |
| gptkbp:mechanismOfAction |
ATP-dependent unwinding of RNA
|
| gptkbp:member |
SF2 superfamily
|
| gptkbp:motif |
DEAD (Asp-Glu-Ala-Asp) sequence
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
neurological disorders viral infection response |
| gptkbp:structure |
conserved helicase core
variable N- and C-terminal extensions |
| gptkbp:bfsParent |
gptkb:DEAD_box_protein_family
|
| gptkbp:bfsLayer |
8
|