|
gptkbp:instanceOf
|
gptkb:protein
gptkb:RNA_helicase
|
|
gptkbp:activityRegulatedBy
|
gptkb:ATP
gptkb:gene
gptkb:eIF4B
eIF4H
|
|
gptkbp:alias
|
Eukaryotic initiation factor 4A
|
|
gptkbp:ATPase_activity
|
yes
|
|
gptkbp:component
|
eIF4F complex
|
|
gptkbp:conservedIn
|
animals
fungi
plants
|
|
gptkbp:EC_number
|
3.6.4.13
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
unwinds secondary structure in 5' UTR of mRNAs
|
|
gptkbp:gene
|
EIF4A1
EIF4A2
EIF4A3
|
|
gptkbp:GO_term
|
GO:0003724
GO:0008026
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
eIF4A
|
|
gptkbp:inhibitedBy
|
hippuristanol
pateamine A
rocaglamide
silvestrol
|
|
gptkbp:interactsWith
|
gptkb:eIF4G
gptkb:eIF4B
eIF4H
|
|
gptkbp:involvedIn
|
translation initiation
|
|
gptkbp:memberOf
|
DEAD-box protein family
|
|
gptkbp:molecularWeight
|
~46 kDa
|
|
gptkbp:orthologIn
|
yeast TIF1
yeast TIF2
|
|
gptkbp:PDB
|
2VSO
|
|
gptkbp:requires
|
cap-dependent translation
|
|
gptkbp:RNA_binding
|
yes
|
|
gptkbp:structure
|
contains two RecA-like domains
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
pateamine A
rocaglamide
silvestrol
|
|
gptkbp:UniProtID
|
P60842
Q14240
Q9UNQ2
|
|
gptkbp:bfsParent
|
gptkb:eIF4E
|
|
gptkbp:bfsLayer
|
7
|