|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Cytochrome_P450_DB1
gptkb:Cytochrome_P450_PCN3
gptkb:Cytochrome_P450_family_3_subfamily_A_member_4
gptkb:CYP3A4
|
|
gptkbp:associatedWith
|
adverse drug reaction
drug interaction
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSP00000290223
1576
|
|
gptkbp:enzymeClassification
|
gptkb:EC_1.14.14.1
|
|
gptkbp:function
|
drug metabolism
monooxygenase
xenobiotic metabolism
|
|
gptkbp:gene
|
gptkb:CYP3A4
|
|
gptkbp:HGNC_ID
|
2623
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P08641
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:St_John's_wort
gptkb:phenytoin
gptkb:carbamazepine
|
|
gptkbp:inhibitedBy
|
gptkb:milk
gptkb:clarithromycin
gptkb:ketoconazole
itraconazole
|
|
gptkbp:length
|
503 amino acids
|
|
gptkbp:locatedOnChromosome
|
7
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:molecularWeight
|
57355 Da
|
|
gptkbp:OMIM
|
124010
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:steroid_hormone_biosynthesis
drug metabolism - cytochrome P450
metabolism of xenobiotics by cytochrome P450
|
|
gptkbp:PDB
|
gptkb:3NXU
gptkb:5TE8
1TQN
4D75
|
|
gptkbp:protein_name
|
gptkb:Cytochrome_P450_3A4
|
|
gptkbp:RefSeq
|
gptkb:NP_017539.1
|
|
gptkbp:substrate
|
gptkb:nifedipine
gptkb:tamoxifen
gptkb:erythromycin
gptkb:midazolam
statins
cyclosporin A
testosterone
|
|
gptkbp:tissue_specificity
|
liver
intestine
|
|
gptkbp:UniProtID
|
gptkb:P08641
|
|
gptkbp:bfsParent
|
gptkb:Ras85D_protein
gptkb:ras85D_(Drosophila_melanogaster)
|
|
gptkbp:bfsLayer
|
6
|