anaphase-promoting complex

URI: https://gptkb.org/entity/anaphase-promoting_complex
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
E3 ubiquitin ligase
gptkbp:alsoKnownAs gptkb:APC/C
gptkbp:biologicalProcess chromosome segregation
exit from mitosis
ubiquitin-protein transferase activity
protein catabolic process
regulation of metaphase/anaphase transition
gptkbp:component gptkb:APC1
gptkb:APC2
gptkb:APC4
gptkb:APC5
gptkb:APC7
gptkb:APC9
gptkb:CDC20
APC10 (DOC1)
APC11
APC13
APC15
APC3 (CDC27)
APC6 (CDC16)
APC8 (CDC23)
CDH1 (FZR1)
gptkbp:discoveredBy gptkb:Marc_Kirschner
gptkbp:discoveredIn 1995
gptkbp:function regulation of cell cycle
ubiquitination of target proteins
triggering anaphase onset
gptkbp:GO_term GO:0005680
https://www.w3.org/2000/01/rdf-schema#label anaphase-promoting complex
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:regulates activated by CDC20
activated by CDH1
inhibited by spindle assembly checkpoint
gptkbp:relatedTo cell division
meiosis
mitosis
gptkbp:species gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
gptkbp:substrate gptkb:cyclin_B
gptkb:securin
aurora kinases
geminin
gptkbp:UniProtID Q9UJX2
gptkbp:bfsParent gptkb:cyclin_B
gptkbp:bfsLayer 6